DNA ligases seal five′-PO4 and three′-OH polynucleotide finishes through three nucleotidyl transfer methods involving ligase-adenylate and DNA-adenylate intermediates. DNA ligases are vital guardians of genomic integrity, and ligase dysfunction underlies human genetic condition syndromes. Crystal structures of DNA ligases sure to nucleotide and nucleic acid substrates have illuminated... https://fun8866298.smblogsites.com/28023781/helping-the-others-realize-the-advantages-of-ligaz-football