This methylation profile is previously acquired within the MBL stage3 and remains comparatively stable after some time. Nevertheless, some CLL have intratumor variability in certain regions, which may change the expression of several genes and facilitate tumor evolution.seventy one Of note, this variability is greater in U-CLL than in M-CLL https://situsjudimbl7704615.blogs100.com/32795080/facts-about-mbl77-revealed