Within the LSD-bound crystal composition, the facet chain in the lid residue L209EL2 sorts considerable hydrophobic contacts with both of those LSD and surrounding residues in TMs III, IV, and V (Determine 4C). When the lid moved apart to show the binding pocket in simulation, many of those contacts broke. https://finnhvflr.blogocial.com/the-fact-about-fractal-storm-self-laid-that-no-one-is-suggesting-70847698