There is a launch of norepinephrine through the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors in the dorsal horn to lower afferent discomfort transmission and develop analgesia. As a result, drugs like clonidine that goal alpha-2 receptors can impact the transmission of suffering. May be specified as monotherapy https://www.proleviate.com/post/the-new-pain-killer-conolidine