Pentobarbital will decrease the level or effect of losartan by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown. pentobarbital will decrease the level or effect of conjugated estrogens, vaginal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. pentobarbital will decrease the level or effect of bexarotene by affecting hepatic/intest... https://bookmarkmiracle.com/story22017512/non-ci-sono-altre-pentobarbital-euthanasia-mechanism-of-action-un-mistero