Exploration into conolidine has triggered discovery of the opioid receptor in the human body termed ACKR3/CXCR7. ACKR3 appears to be probably the most wanted goal for conolidine, which also disregards another four classical opioid receptors(3). Conolidine has become present in the tabernaemontana divaricata plant, which is in the Apocynaceae https://www.proleviate.com/post/conolidine-an-alternative-natural-pain-relief-to-replace-traditional-painkillers